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Immunomodulatory Effects of Vagus Nerve and Acetylcholine in Gastroduodenal Area

Received: 18 March 2014     Accepted: 28 April 2014     Published: 30 May 2014
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Abstract

Objective: Neuroimmune interplay is one of the basic elements that determine mucosal health and disease. Continuing discussion of the vagus nerve in maintenance of homeostasis of gastroduodenal area, we aim to revise immunomodulating effects of acetylcholine. Results: Vagus nerve plays a major role in gut mucosa immunity due to cytoprotective properties and modulation of leukocytes activity. Stimulation of vagus nerve after mucosa damage is accompanied by cholinergic anti-inflammatory pathway that is realized directly through alfa7-nicotinergic cholinoreceptors on neutrophils, macrophages and lymphocytes, which activation causes decrease of NF-kB expression and TNF and IL-6 secretion. Indirect effect of acetylcholine through enteroendocrine cells regulation is quite important in determination of neuro-immune-endocrine interplay in gastroduodenal mucosa. In addition, the changes in vagus nerve activity and neurohumoral control of gastroduodenal area under antisecretory therapy of gastroduodenal diseases are deliberated in this review. Conclusion: Vagus nerve dysfunction is likely to be the main cause of gastroduodenal inflammation, dysregeneration and cancerogenesis.

Published in American Journal of Clinical and Experimental Medicine (Volume 2, Issue 3)
DOI 10.11648/j.ajcem.20140203.11
Page(s) 42-46
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2014. Published by Science Publishing Group

Keywords

Gastroduodenal Pathology, Vagus Nerve, Acetylcholine, Immunomodulation

References
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  • APA Style

    Oksana Sulaieva, Natalia Obraztsova. (2014). Immunomodulatory Effects of Vagus Nerve and Acetylcholine in Gastroduodenal Area. American Journal of Clinical and Experimental Medicine, 2(3), 42-46. https://doi.org/10.11648/j.ajcem.20140203.11

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    ACS Style

    Oksana Sulaieva; Natalia Obraztsova. Immunomodulatory Effects of Vagus Nerve and Acetylcholine in Gastroduodenal Area. Am. J. Clin. Exp. Med. 2014, 2(3), 42-46. doi: 10.11648/j.ajcem.20140203.11

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    AMA Style

    Oksana Sulaieva, Natalia Obraztsova. Immunomodulatory Effects of Vagus Nerve and Acetylcholine in Gastroduodenal Area. Am J Clin Exp Med. 2014;2(3):42-46. doi: 10.11648/j.ajcem.20140203.11

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  • @article{10.11648/j.ajcem.20140203.11,
      author = {Oksana Sulaieva and Natalia Obraztsova},
      title = {Immunomodulatory Effects of Vagus Nerve and Acetylcholine in Gastroduodenal Area},
      journal = {American Journal of Clinical and Experimental Medicine},
      volume = {2},
      number = {3},
      pages = {42-46},
      doi = {10.11648/j.ajcem.20140203.11},
      url = {https://doi.org/10.11648/j.ajcem.20140203.11},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajcem.20140203.11},
      abstract = {Objective: Neuroimmune interplay is one of the basic elements that determine mucosal health and disease. Continuing discussion of the vagus nerve in maintenance of homeostasis of gastroduodenal area, we aim to revise immunomodulating effects of acetylcholine. Results: Vagus nerve plays a major role in gut mucosa immunity due to cytoprotective properties and modulation of leukocytes activity. Stimulation of vagus nerve after mucosa damage is accompanied by cholinergic anti-inflammatory pathway that is realized directly through alfa7-nicotinergic cholinoreceptors on neutrophils, macrophages and lymphocytes, which activation causes decrease of NF-kB expression and TNF and IL-6 secretion. Indirect effect of acetylcholine through enteroendocrine cells regulation is quite important in determination of neuro-immune-endocrine interplay in gastroduodenal mucosa. In addition, the changes in vagus nerve activity and neurohumoral control of gastroduodenal area under antisecretory therapy of gastroduodenal diseases are deliberated in this review. Conclusion: Vagus nerve dysfunction is likely to be the main cause of gastroduodenal inflammation, dysregeneration and cancerogenesis.},
     year = {2014}
    }
    

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  • TY  - JOUR
    T1  - Immunomodulatory Effects of Vagus Nerve and Acetylcholine in Gastroduodenal Area
    AU  - Oksana Sulaieva
    AU  - Natalia Obraztsova
    Y1  - 2014/05/30
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    N1  - https://doi.org/10.11648/j.ajcem.20140203.11
    DO  - 10.11648/j.ajcem.20140203.11
    T2  - American Journal of Clinical and Experimental Medicine
    JF  - American Journal of Clinical and Experimental Medicine
    JO  - American Journal of Clinical and Experimental Medicine
    SP  - 42
    EP  - 46
    PB  - Science Publishing Group
    SN  - 2330-8133
    UR  - https://doi.org/10.11648/j.ajcem.20140203.11
    AB  - Objective: Neuroimmune interplay is one of the basic elements that determine mucosal health and disease. Continuing discussion of the vagus nerve in maintenance of homeostasis of gastroduodenal area, we aim to revise immunomodulating effects of acetylcholine. Results: Vagus nerve plays a major role in gut mucosa immunity due to cytoprotective properties and modulation of leukocytes activity. Stimulation of vagus nerve after mucosa damage is accompanied by cholinergic anti-inflammatory pathway that is realized directly through alfa7-nicotinergic cholinoreceptors on neutrophils, macrophages and lymphocytes, which activation causes decrease of NF-kB expression and TNF and IL-6 secretion. Indirect effect of acetylcholine through enteroendocrine cells regulation is quite important in determination of neuro-immune-endocrine interplay in gastroduodenal mucosa. In addition, the changes in vagus nerve activity and neurohumoral control of gastroduodenal area under antisecretory therapy of gastroduodenal diseases are deliberated in this review. Conclusion: Vagus nerve dysfunction is likely to be the main cause of gastroduodenal inflammation, dysregeneration and cancerogenesis.
    VL  - 2
    IS  - 3
    ER  - 

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Author Information
  • Department of Histology, Cytology and Embryology, M. Gorky Donetsk National Medical University, Ukraine

  • Department of Histology, Cytology and Embryology, M. Gorky Donetsk National Medical University, Ukraine

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